There are a lot of painkillers on the shelves of pharmacies. All of them are sold without a doctor’s prescription, so many people simply abuse them. And the consequences of this kind of behavior can be very serious: often many find with surprise that they received a negative reaction to painkillers. That is, a situation has arisen when one is being cured, the other is crippled.
Is it possible to endure pain
Many believe that pain can be endured. However, in practice, this is not worth it. After all, pain is a natural impulse and reflex of the human body, which occurs as a reaction to various irritating factors. This is a way for the body to say that it is bad and needs help. Accordingly, one cannot tolerate pain; one must necessarily look for the causes of its development and methods of elimination.
Science has proven that ignoring pain is extremely harmful to the body, because when discomfort and painful manifestations appear, nerve endings in the brain die off. In addition, the pain can become chronic. And it also becomes the cause of problems with the cardiovascular system and significantly reduces immunity.
But most often people try not to endure pain, but immediately suppress it with painkillers available at central pharmacy Santa Monica. Fortunately, the modern pharmaceutical industry offers a huge number of non-steroidal anti-inflammatory drugs that are available in pharmacies without prescriptions. However, many, starting to take this kind of drugs, forget that painkillers can be dangerous to health. And with their regular use, including in excess of the prescribed course, such drugs can undermine health even more.
What is the danger of painkillers
There have been many studies that have made an interesting discovery. It turns out that even seemingly harmless ibuprofen or paracetamol can cause serious problems in the human body. So, for example, it was proved that those who took such drugs regularly for 6 or 7 days during the week increased the likelihood of developing hypertension. This is due to the fact that most non-steroidal anti-inflammatory drugs, which are often universally used in the form of commonly available painkillers, inhibit the production of prostaglandins E2 and I2, which have a vasodilating effect. As a result, filtration in the renal glomeruli is significantly reduced, which can lead to fluid retention in the body and an increase in blood pressure. And this, in turn, carries with it the risk of heart attacks or strokes.
Another problem that develops while taking analgesics is the risk of blood clots. To reduce the negative effect of pain medications in cases of gastrointestinal problems, when the important enzyme cyclooxygenase-1 is blocked, NSAIDs have been developed that block mainly another enzyme involved in the development of inflammation and the pathogenesis of pain: cyclooxygenase-2. However, this led to the opposite effect. Such painkillers do not cause problems with the stomach and do not cause bleeding, because there is no COX-2 in the platelets responsible for stopping the bleeding, but this fact helps to increase platelet aggregation and the formation of blood clots. This increases the likelihood of thrombosis, myocardial infarction and ischemic stroke. In this case, it is worthwhile to be especially careful for those who have varicose veins, atherosclerosis, and diabetes mellitus.
Also, non-steroidal anti-inflammatory drugs affect human vision. Due to the use of such drugs in humans, drying of mucous membranes and dehydration of tissues is noted. Prostaglandins blocked by anti-inflammatory drugs cannot expand the vessels, and in smaller arterioles, especially with the development of inflammation, a decrease in red blood cells is formed. At this microscopic level, the oncotic pressure in the lumen of the vessels increases significantly, and the remaining fluid leaves the tissue to dilute the blood and prevent the formation of blood clots. In tissues, temporary dehydration develops. Therefore, doctors, prescribing NSAIDs, recommend a plentiful drink.
Liver problems and photodermatosis can also occur. As a result, a person will notice edema, redness of the skin, a rash that will develop against the background of even a short-term exposure to the sun.
Peter Beaumont is a senior reporter on the Guardian’s Global Development desk. He has reported extensively from conflict zones including Africa, the Balkans and the Middle East and is the author of The Secret Life of War: Journeys Through Modern Conflict. Email: firstname.lastname@example.org